Fibroblast Growth Factor 23 Genotype and Cardiovascular Disease in Patients Undergoing Hemodialysis
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor 23 in patients undergoing peritoneal dialysis.
BACKGROUND AND OBJECTIVES Fibroblast growth factor 23 (FGF23) is an independent risk factor for mortality in patients with ESRD. Before FGF23 testing can be integrated into clinical practice of ESRD, further understanding of its determinants is needed. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS In a study of 67 adults undergoing peritoneal dialysis, we tested the hypothesis that longer dia...
متن کاملIs Fibroblast Growth Factor 23 the New Biomarker for Cardiovascular Mortality in Chronic Kidney Disease Patients?
phosphate co-transporters in the kidney’s proximal tubules [5] . It also directly suppresses renal 1α-hydroxylase, decreasing the rate at which 25-hydroxyvitamin D is converted to its active metabolite, 1,25(OH) 2 D 3 [5] . The serum concentration of FGF23 is also highly correlated with a patient’s cystatin C eGFR [4] . Lastly, FGF23 may cause left ventricular hypertrophy by inducing cardiac my...
متن کاملEffects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
The aim of the present study was to investigate the effects of three blood purification methods on fibroblast growth factor-23 (FGF-23) clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis (MHD). In addition, the correlation between serum FGF-23 and phosphorus (Pi) levels and the clinical implications were identified. Sixty-five MHD patients with hyperphosphatemia we...
متن کاملAlcoholism, Fibroblast Growth Factor 23 and Cardiovascular Risk
Main Findings: Hyperphosphatemia constitutes a major stimulus for FGF-23 secretion, together with infl ammation and reduced iron availability, either by iron defi ciency or by iron sequestration in infl ammatory diseases. FGF-23 can be expressed by the damaged liver. Alcoholism is a proinfl ammatory condition, and in alcoholics there is an increased cardiovascular risk. Preliminary data suggest...
متن کاملFibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Hemodialysis Patients
Background: Left ventricular hypertrophy (LVH) is a common cardiovascular complication and an independent risk factor for cardiovascular death in hemodialysis (HD) patients. Previous studies have shown that fibroblast growth factor 23 (FGF23), which has an important role in phosphate metabolism, is elevated in HD patients. Objectives: The aim of this study was to determine the association of FG...
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ژورنال
عنوان ژورنال: American Journal of Nephrology
سال: 2019
ISSN: 0250-8095,1421-9670
DOI: 10.1159/000496060